{"id":116129,"date":"2025-12-31T15:08:14","date_gmt":"2025-12-31T15:08:14","guid":{"rendered":"https:\/\/ekamu.net\/?p=116129"},"modified":"2025-12-31T15:08:14","modified_gmt":"2025-12-31T15:08:14","slug":"dis-tedavisinde-devrim-dis-kaybi-tarihe-karisabilir","status":"publish","type":"post","link":"https:\/\/ekamu.net\/index.php\/2025\/12\/31\/dis-tedavisinde-devrim-dis-kaybi-tarihe-karisabilir\/","title":{"rendered":"Di\u015f tedavisinde devrim: Di\u015f kayb\u0131 tarihe kar\u0131\u015fabilir"},"content":{"rendered":"

<\/span> Kemikler k\u0131r\u0131ld\u0131\u011f\u0131nda kendini onarabilirken, di\u015fler bu yetene\u011fe sahip de\u011fil. Bu durum, d\u00fcnya genelinde milyonlarca insan\u0131n di\u015f kayb\u0131 ya da do\u011fu\u015ftan di\u015f eksikli\u011fiyle ya\u015famas\u0131na<\/strong> neden oluyor. Ancak Japonya’da yap\u0131lan bir \u00e7al\u0131\u015fma, bu sorunu tamamen ortadan kald\u0131rabilir. Yeni bir tedavi,\u00a0insanlarda di\u015flerin yeniden b\u00fcy\u00fcmesini hedefliyor. <\/figure>\n

Di\u015f kayb\u0131 tarihe kar\u0131\u015fabilir<\/b><\/p>\n

\u0130nsan v\u00fccudu s\u00f6z konusu oldu\u011funda, kemikler k\u0131r\u0131ld\u0131\u011f\u0131nda kendini onarabilen canl\u0131 yap\u0131lar aras\u0131nda yer al\u0131yor. Kalsiyum ve kolajen temelli bu doku, zamanla eski formuna d\u00f6nebiliyor. Di\u015fler ise benzer maddelerden olu\u015fmas\u0131na ra\u011fmen ayn\u0131 avantaja sahip de\u011fil. Mineyle kapl\u0131 olmalar\u0131 onlar\u0131 son derece dayan\u0131kl\u0131 k\u0131lsa da, bir di\u015f kaybedildi\u011finde v\u00fccut bunu telafi edemiyor. Ancak Japon ara\u015ft\u0131rmac\u0131lar\u0131n y\u00fcr\u00fctt\u00fc\u011f\u00fc yeni bir \u00e7al\u0131\u015fma, bunu tersine \u00e7evirebilir.<\/p>\n

Osaka’daki Kitano Hastanesi \u00f6nc\u00fcl\u00fc\u011f\u00fcnde y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fmada, insanlarda di\u015f b\u00fcy\u00fcmesini tetikleyen\u00a0deneysel bir ila\u00e7 ilk kez klinik denemelere<\/strong> girdi. Eyl\u00fcl 2024’te ba\u015flayan \u00e7al\u0131\u015fmada, 30 ila 64 ya\u015f aras\u0131nda, en az bir di\u015fini kaybetmi\u015f 30 erkek g\u00f6n\u00fcll\u00fc<\/strong> yer al\u0131yor. Ara\u015ft\u0131rma 11 ay s\u00fcrecek ve ilac\u0131n damar yoluyla uygulanmas\u0131 planlan\u0131yor.<\/p>\n

Bu tedavinin temelinde, USAG-1 adl\u0131 bir antikorun bask\u0131lanmas\u0131 yat\u0131yor. Daha \u00f6nce fareler ve gelincikler \u00fczerinde yap\u0131lan deneylerde, USAG-1’in di\u015f geli\u015fimini engelledi\u011fi, bu etkinin ortadan kald\u0131r\u0131lmas\u0131yla yeni di\u015f olu\u015fumunun m\u00fcmk\u00fcn hale geldi\u011fi<\/strong> g\u00f6r\u00fclm\u00fc\u015ft\u00fc. Kyoto \u00dcniversitesi’nden ara\u015ft\u0131rmac\u0131lar, 2021 y\u0131l\u0131nda USAG-1 ile kemik morfogenetik proteinler (BMP) aras\u0131ndaki etkile\u015fimi kesen monoklonal bir antikor geli\u015ftirmi\u015fti.<\/p>\n

Klinik denemeler ba\u015flad\u0131<\/b><\/p>\n

\u00c7al\u0131\u015fman\u0131n yazarlar\u0131ndan Katsu Takahashi’ye g\u00f6re, gelinciklerin di\u015f yap\u0131s\u0131 insanlara olduk\u00e7a benzer oldu\u011fu i\u00e7in elde edilen sonu\u00e7lar \u00f6zellikle dikkat \u00e7ekici. \u015eimdi benzer etkinin insanlarda da g\u00f6r\u00fcl\u00fcp g\u00f6r\u00fclmeyece\u011fi test ediliyor. Hayvan deneylerinde herhangi bir yan etkiye rastlanmam\u0131\u015f<\/strong> olmas\u0131 ise, ara\u015ft\u0131rman\u0131n en g\u00fc\u00e7l\u00fc yanlar\u0131ndan biri.<\/p>\n

\u0130lk a\u015fama ba\u015far\u0131l\u0131 olursa, Kitano Hastanesi tedaviyi 2 ila 7 ya\u015f aras\u0131nda, en az d\u00f6rt di\u015fi eksik olan \u00e7ocuklar \u00fczerinde uygulamay\u0131<\/strong> planl\u0131yor. Nihai hedef ise, di\u015f kayb\u0131 ya\u015fayan herkes i\u00e7in 2030 y\u0131l\u0131 civar\u0131nda eri\u015filebilir bir “di\u015f \u00e7\u0131karan ila\u00e7” <\/strong>sunabilmek. Ara\u015ft\u0131rmac\u0131lara g\u00f6re bu yakla\u015f\u0131m, implant ve protez gibi \u00e7\u00f6z\u00fcmlerin \u00f6tesine ge\u00e7erek di\u015f hekimli\u011finde kal\u0131c\u0131 ve biyolojik bir alternatifin \u00f6n\u00fcn\u00fc a\u00e7abilir.\u00a0<\/p>\n\n

<\/span><\/p>\n

Kaynak :\u00a0https:\/\/www.donanimhaber.com\/dis-tedavisinde-devrim-dis-kaybi-tarihe-karisabilir–200347<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Kemikler k\u0131r\u0131ld\u0131\u011f\u0131nda kendini onarabilirken, di\u015fler bu yetene\u011fe sahip de\u011fil. Bu durum, d\u00fcnya genelinde milyonlarca insan\u0131n di\u015f kayb\u0131 ya da do\u011fu\u015ftan di\u015f eksikli\u011fiyle ya\u015famas\u0131na neden oluyor. Ancak Japonya’da yap\u0131lan bir \u00e7al\u0131\u015fma, bu sorunu tamamen …<\/p>\n","protected":false},"author":1,"featured_media":116130,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[314,589,882,420],"class_list":["post-116129","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-teknoloji","tag-arastirma","tag-dis","tag-ila","tag-insan"],"_links":{"self":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts\/116129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/comments?post=116129"}],"version-history":[{"count":1,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts\/116129\/revisions"}],"predecessor-version":[{"id":116132,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts\/116129\/revisions\/116132"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/media\/116130"}],"wp:attachment":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/media?parent=116129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/categories?post=116129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/tags?post=116129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}