{"id":116635,"date":"2026-01-05T08:08:07","date_gmt":"2026-01-05T08:08:07","guid":{"rendered":"https:\/\/ekamu.net\/?p=116635"},"modified":"2026-01-05T08:08:07","modified_gmt":"2026-01-05T08:08:07","slug":"tamamen-yapay-zeka-ile-tasarlanan-bir-ilac-tarihte-ilk-kez-onay-oncesi-son-asamaya-geldi","status":"publish","type":"post","link":"https:\/\/ekamu.net\/index.php\/2026\/01\/05\/tamamen-yapay-zeka-ile-tasarlanan-bir-ilac-tarihte-ilk-kez-onay-oncesi-son-asamaya-geldi\/","title":{"rendered":"Tamamen yapay zeka ile tasarlanan bir ila\u00e7, tarihte ilk kez onay \u00f6ncesi son a\u015famaya geldi"},"content":{"rendered":"

<\/span> Yapay zeka alan\u0131nda ya\u015fanan patlama, farkl\u0131 alanlarda da teknolojik s\u0131\u00e7ramalar\u0131 tetiklemeye devam ediyor. Son aylarda ya\u015fananlar, ila\u00e7 end\u00fcstrisinin de bunlardan biri olaca\u011f\u0131n\u0131 g\u00f6steriyor. Nitekim bu alanda \u00f6nemli bir e\u015fik a\u015f\u0131lmak \u00fczere. Insilico Medicine<\/strong> taraf\u0131ndan tamamen yapay zeka ile tasarlanan ilk ila\u00e7<\/strong>, onay \u00f6ncesi son a\u015fama olan Faz 3 klinik denemelere girmek \u00fczere. <\/figure>\n

Rentosertib<\/strong> ad\u0131 verilen bu deneysel ila\u00e7, \u00f6l\u00fcmc\u00fcl bir akci\u011fer hastal\u0131\u011f\u0131 olan idiyopatik pulmoner fibrozun tedavisi i\u00e7in geli\u015ftirildi. <\/strong>S\u00f6z konusu hastal\u0131k yaln\u0131zca ABD\u2019de her y\u0131l yakla\u015f\u0131k 40 bin ki\u015finin hayat\u0131n\u0131 kaybetmesine yol a\u00e7\u0131yor ve mevcut tedaviler hastal\u0131\u011f\u0131n seyrini durdurmakta olduk\u00e7a s\u0131n\u0131rl\u0131 kal\u0131yor. Haziran ay\u0131nda Nature Medicine\u2019da yay\u0131mlanan Faz 2 sonu\u00e7lar\u0131, Rentosertib\u2019in bu alanda umut verici sonu\u00e7lar ortaya koydu\u011funu g\u00f6steriyor.<\/strong><\/p>\n

\u00c7in\u2019de y\u00fcr\u00fct\u00fclen ve 71 hastay\u0131 kapsayan \u00e7al\u0131\u015fmada, ilac\u0131 en y\u00fcksek dozda (60 mg) alan hastalarda akci\u011fer kapasitesini g\u00f6steren \u201czorlanm\u0131\u015f vital kapasite\u201d de\u011ferinde ortalama 98,4 mL\u2019lik bir art\u0131\u015f g\u00f6zlemlenirken, plasebo grubunda ortalama 20,3 mL\u2019lik bir d\u00fc\u015f\u00fc\u015f kaydedildi. \u00dcstelik bu iyile\u015fme, ciddi yan etkiler rapor edilmeden elde edildi.<\/p>\n

Rentosertib\u2019i as\u0131l s\u0131ra d\u0131\u015f\u0131 k\u0131lan nokta ise yaln\u0131zca klinik sonu\u00e7lar\u0131 de\u011fil, geli\u015ftirilme h\u0131z\u0131. Geleneksel ila\u00e7 ke\u015ffi s\u00fcre\u00e7lerinde bir molek\u00fcl\u00fcn insan \u00fczerinde test edilecek a\u015famaya gelmesi genellikle 4 ila 5 y\u0131l s\u00fcrerken, Insilico bu s\u00fcreyi iki y\u0131l\u0131n alt\u0131na indirmeyi ba\u015fard\u0131.<\/strong> \u015eirket, kendi geli\u015ftirdi\u011fi yapay zeka platformu sayesinde yaln\u0131zca 78 molek\u00fcl\u00fc taray\u0131p test ederek 18 ay gibi k\u0131sa bir s\u00fcrede erken ke\u015fif a\u015famas\u0131n\u0131 tamamlad\u0131. Bu \u00e7al\u0131\u015fma, yapay zekan\u0131n farmakoloji alan\u0131nda Ar-Ge verimlili\u011fini dramatik bi\u00e7imde art\u0131rabildi\u011fini<\/strong> g\u00f6steren en somut \u00f6rneklerden biri olarak de\u011ferlendiriliyor.<\/p>\n

E\u011fer Faz 3 denemeler de ba\u015far\u0131yla tamamlan\u0131r ve d\u00fczenleyici onay al\u0131n\u0131rsa, Rentosertib tamamen yapay zeka taraf\u0131ndan ke\u015ffedilip tasarlanan ilk onayl\u0131 ila\u00e7 olarak tarihe ge\u00e7ebilir<\/strong>. Bu da yaln\u0131zca pulmoner fibroz i\u00e7in de\u011fil, ila\u00e7 geli\u015ftirme s\u00fcre\u00e7lerinin tamam\u0131 i\u00e7in yeni bir \u00e7a\u011f\u0131n kap\u0131s\u0131n\u0131 aralayabilir.<\/p>\n

Yapay Zeka Destekli \u0130la\u00e7 Projelerine Yat\u0131r\u0131m H\u0131zla Art\u0131yor<\/b><\/p>\n

Bu geli\u015fme, yat\u0131r\u0131mc\u0131lar\u0131n yapay zeka destekli ila\u00e7 ke\u015ffine olan ilgisinin neden son d\u00f6nemde h\u0131zla artt\u0131\u011f\u0131n\u0131 da a\u00e7\u0131kl\u0131yor. PitchBook verilerine g\u00f6re, 2025\u2019in ilk \u00fc\u00e7 \u00e7eyre\u011finde yaln\u0131zca bu alana odaklanan \u015firketlere toplam 2,7 milyar dolarl\u0131k giri\u015fim sermayesi yat\u0131r\u0131m\u0131 yap\u0131ld\u0131<\/strong>. K\u00fcresel ila\u00e7 sekt\u00f6r\u00fcn\u00fcn yapay zeka yat\u0131r\u0131mlar\u0131n\u0131n 2034\u2019te ise 16,5 milyar dolara kadar \u00e7\u0131kmas\u0131 bekleniyor.<\/p>\n

B\u00fcy\u00fck ila\u00e7 \u015firketleri de bu yar\u0131\u015fta geri kalmamak i\u00e7in agresif ad\u0131mlar at\u0131yor. Ekim 2025\u2019te Eli Lilly, Nvidia ile ortakl\u0131k kurarak bir ila\u00e7 \u015firketine ait \u201cen g\u00fc\u00e7l\u00fc s\u00fcper bilgisayar\u201d olaca\u011f\u0131n\u0131 iddia etti\u011fi bir sistem in\u015fa edece\u011fini duyurdu. Ocak 2026\u2019da devreye girmesi planlanan ve binin \u00fczerinde GPU bar\u0131nd\u0131racak bu altyap\u0131<\/strong>, milyonlarca potansiyel ilac\u0131n ayn\u0131 anda tasarlan\u0131p test edilebildi\u011fi bir \u201cyapay zeka fabrikas\u0131\u201d olarak konumland\u0131r\u0131l\u0131yor. Benzer \u015fekilde, OpenAI destekli Chai Discovery de yapay zekayla yeni ila\u00e7lar geli\u015ftirme konusunda dikkat \u00e7ekici \u00e7al\u0131\u015fmalar imza at\u0131yor. T\u00fcm bu geli\u015fmeler, yapay zekanan ila\u00e7 geli\u015ftirme s\u00fcre\u00e7lerini de k\u00f6kten de\u011fi\u015ftirmek \u00fczere<\/strong> oldu\u011funu g\u00f6steriyor.<\/p>\n\n

<\/span><\/p>\n

Kaynak :\u00a0https:\/\/www.donanimhaber.com\/yapay-zeka-ile-tasarlanan-bir-ilac-ilk-kez-onay-asamasina-geldi–200471<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Yapay zeka alan\u0131nda ya\u015fanan patlama, farkl\u0131 alanlarda da teknolojik s\u0131\u00e7ramalar\u0131 tetiklemeye devam ediyor. Son aylarda ya\u015fananlar, ila\u00e7 end\u00fcstrisinin de bunlardan biri olaca\u011f\u0131n\u0131 g\u00f6steriyor. Nitekim bu alanda \u00f6nemli bir e\u015fik a\u015f\u0131lmak \u00fczere. Insilico …<\/p>\n","protected":false},"author":1,"featured_media":116636,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[78,101,6565,421],"class_list":["post-116635","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-teknoloji","tag-alan","tag-ilac","tag-yalnizca","tag-yapay-zeka"],"_links":{"self":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts\/116635","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/comments?post=116635"}],"version-history":[{"count":1,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts\/116635\/revisions"}],"predecessor-version":[{"id":116638,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts\/116635\/revisions\/116638"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/media\/116636"}],"wp:attachment":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/media?parent=116635"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/categories?post=116635"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/tags?post=116635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}