{"id":8047,"date":"2024-05-31T04:24:11","date_gmt":"2024-05-31T04:24:11","guid":{"rendered":"https:\/\/ekamu.net\/?p=8047"},"modified":"2024-05-31T04:24:11","modified_gmt":"2024-05-31T04:24:11","slug":"dunyanin-ilk-dis-buyutme-ilaci-insanlar-uzerinde-denenecek","status":"publish","type":"post","link":"https:\/\/ekamu.net\/index.php\/2024\/05\/31\/dunyanin-ilk-dis-buyutme-ilaci-insanlar-uzerinde-denenecek\/","title":{"rendered":"D\u00fcnyan\u0131n ilk di\u015f b\u00fcy\u00fctme ilac\u0131 insanlar \u00fczerinde denenecek"},"content":{"rendered":"

<\/span> Kyoto \u00dcniversitesi Hastanesi <\/strong>di\u015fleri yenileyebilen ilac\u0131n\u0131n d\u00fcnyadaki ilk insan denemesini Eyl\u00fcl 2025<\/strong> tarihine kadar tamamlamay\u0131 ama\u00e7l\u0131yor. Ger\u00e7ekle\u015ftirilecek olan denemelerde en az bir az\u0131 di\u015fi eksik olan 30-64 ya\u015flar\u0131ndaki 30 erkek tedavi edilecek. <\/figure>\n

Ba\u015far\u0131l\u0131 olmas\u0131 durumunda kal\u0131c\u0131 di\u015f eksikli\u011fi olan hastalara uygulanabilecek<\/b><\/p>\n

Damar i\u00e7i tedavi<\/strong> ile gelincik ve fare modellerinde hi\u00e7bir \u00f6nemli yan etki olmaks\u0131z\u0131n ba\u015far\u0131l\u0131 bir \u015fekilde yeni di\u015fler \u00fcretildi. Bunun \u00fczerine insan di\u015fleri \u00fczerindeki etkinli\u011finin test edilmeye ba\u015flanmas\u0131na karar verildi.<\/p>\n

11 ayl\u0131k ilk a\u015faman\u0131n ard\u0131ndan ara\u015ft\u0131rmac\u0131lar, ilac\u0131, insanlar\u0131n y\u00fczde 1’ini etkiledi\u011fi tahmin edilen do\u011fu\u015ftan di\u015f eksikli\u011fi nedeniyle en az d\u00f6rt di\u015fi eksik olan 2-7 ya\u015f<\/strong> aras\u0131 hastalar \u00fczerinde deneyecek.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar daha sonra denemeyi k\u0131smi di\u015fsizli\u011fi olan veya \u00e7evresel fakt\u00f6rler nedeniyle 1 ila 5 kal\u0131c\u0131 di\u015fi eksik olan ki\u015fileri kapsayacak \u015fekilde geni\u015fletmeyi planl\u0131yor. Bunun g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 ise \u00fclkeden \u00fclkeye de\u011fi\u015fiyor.<\/p>\n

\u0130la\u00e7, di\u015f b\u00fcy\u00fcmesini bask\u0131layan rahim duyarl\u0131l\u0131\u011f\u0131yla ili\u015fkili USAG-1 proteinini devre d\u0131\u015f\u0131 b\u0131rak\u0131yor. USAG-1’in di\u011fer proteinlerle etkile\u015fiminin engellenmesi ise yeni kemik olu\u015fumuna yard\u0131mc\u0131 olan Kemik Morfogenetik Proteini’ni (BMP -Bone Morphogenetic Protein) tetikliyor. Bu protein sayesinde yumu\u015fak dokularda kemikle\u015fme ya\u015fan\u0131yor ve sonras\u0131nda di\u015fin b\u00fcy\u00fcmesi ger\u00e7ekle\u015fiyor.<\/p>\n

\u0130nsanlarla neredeyse ayn\u0131 USAG-1 \u00f6zelliklerini payla\u015fan t\u00fcrler olan fare ve gelinciklerin a\u011f\u0131zlar\u0131nda yeni di\u015flerin ortaya \u00e7\u0131kmas\u0131yla sonu\u00e7land\u0131. Ara\u015ft\u0131rmac\u0131lar, USAG-1 proteininin insanlar ve fareler dahil olmak \u00fczere farkl\u0131 t\u00fcrler aras\u0131nda %97’lik y\u00fcksek bir amino asit homolojisine sahip oldu\u011funu d\u00fc\u015f\u00fcn\u00fcyor.<\/p>\n

Molek\u00fcler biyolog ve di\u015f hekimi Takahashi<\/strong>, di\u015f kayb\u0131 veya yoklu\u011fundan muzdarip olanlara yard\u0131m etmek i\u00e7in bir \u015feyler yapmak istediklerini ve bug\u00fcne kadar kal\u0131c\u0131 bir tedavi olmamas\u0131na ra\u011fmen insanlar\u0131n di\u015f b\u00fcy\u00fcmesine ili\u015fkin beklentilerinin y\u00fcksek oldu\u011funu belirtti.<\/p>\n

Takahashi, 2005 y\u0131l\u0131ndan bu yana di\u015f rejenerasyonu \u00fczerinde \u00e7al\u0131\u015ft\u0131klar\u0131n\u0131 ve bu tedavinin sadece do\u011fu\u015ftan di\u015f hastal\u0131klar\u0131 i\u00e7in de\u011fil her ya\u015fta di\u015f kaybetmi\u015f herkes i\u00e7in bir umut oldu\u011funu belirtti.<\/p>\n

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Daha Fazla Video <\/div>\n
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<\/p>\n
donanimhabercom Instagram <\/span> Takip Et <\/p>\n

Xiaomi’den f\u00fct\u00fcristik su tabancas\u0131<\/p>\n<\/div>\n<\/p><\/div>\n

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<\/p>\n
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Exadious 2 ay \u00f6nce<\/span> <\/div>\n

Efsane T\u00fcrkiye\u2019ye gelse al\u0131r\u0131m..<\/p>\n<\/div>\n<\/p><\/div>\n

E <\/p>\n
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E_Y_B_H_P_T 2 ay \u00f6nce<\/span> <\/p>\n
2<\/span> <\/div>\n<\/p><\/div>\n

O \u0131\u015f\u0131k efektleri sadece yanlarda de\u011fil \u00fcstte de olmal\u0131yd\u0131. B\u00f6ylece tabancay\u0131 kullanan, kafas\u0131n\u0131 yana e\u011fmek zorunda kal\u0131p, f\u0131t\u0131k olmaz. Ayn\u0131s\u0131n\u0131 k\u00fc\u00e7\u00fckken \u0131\u015f\u0131kl\u0131 ayakkab\u0131mda ya\u015fam\u0131\u015ft\u0131m oradan biliyorum. Ayakkab\u0131ma yan bakmaktan d\u00fcz y\u00fcr\u00fcyemiyordum. Hava atmaktan ziyade o havay\u0131 ya\u015famay\u0131 tercih ederim. 7 de olsam 70 de olsam karar\u0131m de\u011fi\u015fmeyecek.<\/p>\n<\/div>\n<\/p><\/div>\n

<\/p>\n
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emrahmt 3 ay \u00f6nce<\/span> <\/div>\n

Mukemmel bir silah acaba ne kadar h\u0131zl\u0131 at\u0131yor. [resim]<\/p>\n<\/div>\n<\/p><\/div>\n

<\/p>\n
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garez41 4 ay \u00f6nce<\/span> <\/div>\n

Fiyat makul olsa efsane olur ger\u00e7ekten ya.<\/p>\n<\/div>\n<\/p><\/div>\n

<\/p>\n
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Rindaman 5 ay \u00f6nce<\/span> <\/div>\n

Vay bee, bu cihaz xiaomi \u00e7\u0131kt\u0131 ben de diyordum kim \u00fcretmi\u015f..<\/p>\n<\/div>\n<\/p><\/div>\n

D <\/p>\n
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DH Misafiri 5 ay \u00f6nce<\/span> <\/div>\n

hocam 4x daha iyi direk hs attirir<\/p>\n<\/div>\n<\/p><\/div>\n

<\/p>\n
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Mstt.2010 7 ay \u00f6nce<\/span> <\/div>\n

\u00dcber<\/p>\n<\/div>\n<\/p><\/div>\n

<\/p>\n
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SUPERSONICQ 7 ay \u00f6nce<\/span> <\/div>\n

Evet ama 6x scop daha iyi gider buna daha uzaktaki hedefler i\u00e7in. Gerekti\u011finde 3x’e de \u00e7ekebilirsin falan :D<\/p>\n<\/div>\n<\/p><\/div>\n

<\/p>\n
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SupremeMasterr 7 ay \u00f6nce<\/span> <\/div>\n

Muskun alev tabancas\u0131 vs bu<\/p>\n<\/div>\n<\/p><\/div>\n

<\/p>\n
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ccguven 8 ay \u00f6nce<\/span> <\/p>\n
2<\/span> <\/div>\n<\/p><\/div>\n

\u0130stilac\u0131 g\u00fcvercinlere kar\u015f\u0131 iyi olur. 5 10 dk da bir sopay\u0131 al\u0131p kovalamak yordu art\u0131k.<\/p>\n<\/div>\n<\/p><\/div>\n

<\/p>\n
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rszx247 8 ay \u00f6nce<\/span> <\/div>\n

Yak\u0131nda su atan F18 falanda yaparlar :)<\/p>\n<\/div>\n<\/p><\/div>\n

X <\/p>\n
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xsw 8 ay \u00f6nce<\/span> <\/p>\n
1<\/span> <\/div>\n<\/p><\/div>\n

Hazneye kezzapl\u0131 su doldurup ni\u015fan almak yapmay\u0131n b\u00f6yle \u015feyler yahu…<\/p>\n<\/div>\n<\/p><\/div>\n

<\/p>\n
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alex59 9 ay \u00f6nce<\/span> <\/p>\n
2<\/span> <\/div>\n<\/p><\/div>\n

Xiaomi kendini \u00e7ok geli\u015ftirdi art\u0131k her alanda kaliteli i\u015fler yap\u0131yorlar.<\/p>\n<\/div>\n<\/p><\/div>\n

<\/p>\n
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Rhodope Thrax 9 ay \u00f6nce<\/span> <\/div>\n

f\u0131\u015fk\u0131rtt\u0131\u011f\u0131 su mermi gibi isabetli gitmeyece\u011fi i\u00e7in gereksiz diye d\u00fc\u015f\u00fcnm\u00fc\u015f olabilirler.<\/p>\n<\/div>\n<\/p><\/div>\n

<\/p>\n
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RaptorFX 9 ay \u00f6nce<\/span> <\/div>\n

Lazer ni\u015fangah da eklenseymi\u015f tad\u0131ndan yenmezmi\u015f.<\/p>\n<\/div>\n<\/p><\/div>\n

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Kaynak :\u00a0https:\/\/www.donanimhaber.com\/dunyanin-ilk-dis-buyutme-ilaci-insanlar-uzerinde-denenecek–177864<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Kyoto \u00dcniversitesi Hastanesi di\u015fleri yenileyebilen ilac\u0131n\u0131n d\u00fcnyadaki ilk insan denemesini Eyl\u00fcl 2025 tarihine kadar tamamlamay\u0131 ama\u00e7l\u0131yor. Ger\u00e7ekle\u015ftirilecek olan denemelerde en az bir az\u0131 di\u015fi eksik olan 30-64 ya\u015flar\u0131ndaki 30 erkek tedavi …<\/p>\n","protected":false},"author":1,"featured_media":8048,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[589,420,590,119,313],"class_list":["post-8047","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-teknoloji","tag-dis","tag-insan","tag-protein","tag-yan","tag-yas"],"_links":{"self":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts\/8047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/comments?post=8047"}],"version-history":[{"count":1,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts\/8047\/revisions"}],"predecessor-version":[{"id":8109,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/posts\/8047\/revisions\/8109"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/media\/8048"}],"wp:attachment":[{"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/media?parent=8047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/categories?post=8047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ekamu.net\/index.php\/wp-json\/wp\/v2\/tags?post=8047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}